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John Clayton discusses the potential fallout of Bills defensive end Mario Williams' use of "kill 'em or hurt 'em" when describing direction taken from defensive coordinator Mike Pettine.

Inside the Huddle's John Clayton goes deep into the off-season tweaks and fixes being made by the San Diego Chargers, Buffalo Bills, Kansas City Chiefs and Miami Dolphins.

Jamaal Charles, LeSean McCoy and C.J. Spiller have plenty of speed and breakaway ability but who do you want for 2013? ESPN fantasy analysts debate which running back to draft this season.

Dr. Michael Kaplan discusses the recovery process facing Jim Kelly following surgery to remove cancer from his jaw.

Mike Golic and Mike Greenberg react to the news that Buffalo Bills Hall of Fame QB Jim Kelly has been diagnosed with cancer in his upper jaw bone.

Skip Bayless, Pelicans guard Austin Rivers and Stephen A. Smith discuss whether it was smart for Bills rookie QB EJ Manuel to say the offense was less complex than the system he used at Florida State.

Herm Edwards discusses the spring goals and decisions facing new NFL head coaches.

ESPN.com AFC East blogger James Walker discusses Buddy Nix's decision to step down as the Buffalo Bills' general manager.

John Clayton discovers early-round tackles getting more time to develop, Le'Veon Bell an all-purpose option for Roethlisberger, DEs turning into OLB & the Bears' offensive line revamping.

Phil Murphy talks with former Seminoles quarterback E.J. Manuel about the transition from Bobby Bowden to Jimbo Fisher, passing the torch to new quarterback Jameis Winston and lessons learned at Florida State that will help upon arrival in Buffalo.

In this edition of Throwback Thursday, Tom Luginbill takes three current ESPN 150 athletes and looks at which former college standouts they remind him of.

Tim Hasselbeck discusses whether Jets QB Geno Smith and Bills QB EJ Manuel will start Week 1 of the 2013 season.

Mel Kiper Jr., Todd McShay and Bill Polian discuss their winners and losers from the 2013 NFL draft.

Bills coach Doug Marrone discusses why the Bills made EJ Manuel the first QB picked in the draft.

Inside the Huddle's John Clayton goes deep on Patriot receivers, experienced kickers, Raiders free agency and converting a DE to an OLB.

Episode 303: Former Detroit Lions running back Barry Sanders discusses how Reggie Bush will fit with the Lions offense. The NFL32 crew break down Ryan Nassib and where he could end up in the Draft.