Cristian Tello bagged a brace while Thiago was also on target as Barcelona eased to a -30 victory over Real Zaragoza at La Romareda on Sunday.
Robert Lewandowski scored a brace as Borussia Dortmund bounced back from its midweek cup loss to Bayern Munich with a 3-1 Bundesliga victory over Hannover.
Gareth Bale lived up to his billing as Tottenham's own Cristiano Ronaldo after firing Andre Villas-Boas' side to an entertaining 2-1 victory over Newcastle at White Hart Lane on Saturday.
Bayern Munich continued its seemingly unstoppable march toward the Bundesliga title with a convincing 3-0 win at Mainz on Saturday afternoon.
Manchester United was forced to survive a second-half Southampton bombardment before edging seven points clear in the Premier League title race with a 2-1 win Wednesday.
Luis Fabiano netted a first-half brace as Brazilian giants Sao Paulo hammered Bolivia's Bolivar 5-0 on its road to the Copa Libertadores group stage.
Paul Pogba struck a brilliant brace as Juventus extended their lead at the top of Serie A to five points over Lazio and six over Napoli with a 4-0 home win over Udinese.
Striker Luis Suarez scored two goals as Liverpool beat Sunderland 3-0 at Anfield.
Jozy Altidore bagged a brace Saturday as AZ Alkmaar won 2-1 at 10-man Zwolle.
Fabio Quagliarella's brace earned Juventus a comfortable 2-0 win against Chievo tonight to preserve their 100% record in Serie A.
Gervinho's brace helped Arsenal romp to an impressive 6-1 Barclays Premier League victory against Southampton on Saturday.