USC can't afford to look past its Sun Bowl matchup with a Georgia Tech team that runs a unique and difficult triple-option offense.
While this year's version of the USC-Notre Dame rivalry has huge implications for the Irish, the Trojans are reduced to playing spoiler.
The crosstown showdown between USC and UCLA has big implications, as a trip to the Pac-12 title game is at stake.
In a battle between two struggling teams, USC and Arizona State square off in a big Pac-12 South Division contest.
Oregon's last loss came last November at the hands of USC, so it's safe to say that the No. 4 Ducks will be ready for the Trojans this time around.
Colorado has been scuffling en route to a 1-5 start, not the best way to enter a game against USC.
Utah and its strong front seven look to bounce back from a 37-7 loss to Arizona State against USC.
A statistical breakdown of the remaining opponents on USC's schedule.
USC has won eight in a row against the Bears, but Cal looks to snap that streak on the heels of a strong performance against Ohio State.
Syracuse's offense, led by senior quarterback Ryan Nassib, can pass with anyone, but can the Orange put up enough points to hang with the No. 2-ranked USC Trojans?
While some of the focus Saturday will shift to Norm Chow returning against USC as a head coach, Hawaii faces quite the (obvious) test on the field, particularly with an unproven starter at the helm in QB Sean Schroeder.