The feel-good story of last year and the defending Super Bowl champions will square off in Week 1 when the Saints travel to Indianapolis to take on the Colts in the NFL's first game of the season.
The Giants may not be playing for only a playoff berth; they may be playing to save Tom Coughlin's job. That's just one of the intriguing subplots of Week 17, writes John Clayton.
Jeff Garcia and the Eagles can inch closer to the NFC East title when they visit Dallas, and tweak T.O. as well in a game that highlights Week 16, writes John Clayton.
The Saints-Cowboys tilt highlights a Week 14 that features numerous games with playoff implications, writes John Clayton.
The Cowboys-Giants rematch highlights Week 13 and so much has happened since the first time they met, most of it good for Dallas and bad for New York, writes John Clayton.
John Clayton breaks down the best games of Week 15, highlighted by the Colts' playing host to the Bengals on "MNF" in a battle between teams heading in opposite directions.
While Indy-Philly once looked like the marquee matchup, it's a possible Super Bowl preview when the Bears visit the Patriots that highlights Week 12, writes John Clayton.
Things are heating up in the AFC West and the battle between the Broncos and the red-hot Chargers highlights Week 11, writes John Clayton.
The Bears and Giants have emerged at the NFC's best. Their matchup in the Meadowlands highlights an interesting Week 10, writes John Clayton.
Colts-Patriots. Manning-Brady. It doesn't get much better than this. Indy's trip to New England highlights an intriguing Week 9, writes John Clayton.
How good is the Denver defense? We'll know more after the Broncos play Indianapolis. John Clayton breaks down that game and more in his preview of Week 8.
T.O. in prime time, the Steve Hutchinson Bowl and how the Bengals' offense can improve are just a few of the highlights of Week 7, writes John Clayton.
The Rams are 4-1. But are they for real? Sunday's matchup with the Seahawks could answer that question, writes John Clayton in his preview of Week 6.
Forget T.O.'s return to Philly. The Cowboys-Eagles game itself means much more in a week of intriguing divisional matchups that highlight Week 5, writes John Clayton.
A sneak peak at some potential playoff matchups and some heavyweight defensive battles highlight Week 4, writes John Clayton.
John Clayton discusses the best games of Week 3, highlighted by the Colts playing host to the Jags in a key AFC South battle.