Can anyone stop Peyton Manning and the Colts? The Steelers will try Monday night in Week 12's best game.
Already 0-2 in the division, the Eagles can ill afford to lose to the Cowboys. Their MNF game is John Clayton's top matchup of Week 10.
There is a lot on the line when the Patriots host the Colts on Monday night in John Clayton's top matchup of Week 9.
With injuries to key players, the Eagles could see their undefeated run end against the Steelers.
The Seahawks' late collapse last week has increased the importance of Sunday's game at New England.
A win at home against the Rams on Sunday would give Seattle a nice cushion in the NFC West.
The stingy Jaguars defense will be tested Sunday against the Colts, who have scored 100 points so far.
Sunday night's Chiefs-Broncos showdown is among the weekend's most impressive matchups.
The Vikings and Chiefs bring high-powered offenses into the best matchup of Week 16.
Peyton Manning and the Colts go for the sweep of the Titans in the top matchup of a loaded Week 14.
Two of the NFC's best teams -- the Panthers and Cowboys -- meet in the best matchup of Week 12.
It's a battle of unbeatens as the Colts play host to the Panthers in Week 6's best matchup.
They're not division rivals anymore, but Pittsburgh vs. Tennessee is still Week 4's biggest matchup.
The Broncos host the Raiders on Monday night in Week 3's biggest matchup.
With playoff spots on the line in nearly every game, it will be a wild weekend in the NFL.
The Broncos and Raiders meet Sunday in a game that has huge playoff ramifications.