Which No. 1 has the toughest road to New Orleans? The Fighting Irish have to travel to Iowa and would play the second round in Norfolk, Va.
When the Sweet 16 gets under way on Saturday afternoon, some of the biggest stars on the court will be the smallest players on the court, the point guards.
A spot in the Sweet 16 is at stake for the teams in Monday's second-round matchups.
From the best place to be for the first weekend to the teams that should be on upset alert, Graham Hays looks at the bracket's biggest questions.