Grambling remained unbeaten in the SWAC West and is on a collision course with Southern for the division title.
North Carolina A&T was blown out by S.C. State, helping Bethune-Cookman qualify for the I-AA playoffs.
Fayetteville State, Albany State and North Carolina A&T wrapped up conference titles last weekend.
Alcorn State handed Southern University its first loss, and Alabama A&M held off Alabama State in the Magic City Classic.
Southern and Grambling recovered from slow starts to remain undefeated in SWAC play and tied atop the West division.
Southern University remained the only undefeated team in Black College football with a 55-25 victory over Alabama A&M.
Hampton and Morgan State went to overtime before the Pirates prevailed. Plus, Southern smothered Alabama State.
Hampton and South Carolina State scored identical 53-0 wins in classic games this weekend, but Grambling fell at home.
Southern University remained undefeated and Grambling posted its second straight impressive victory over the weekend.
The CIAA swept the SIAC while the MEAC topped the SWAC 2-1 in interconference matchups over the weekend.