It was already a tough existence for the American women, but when Madison Keys withdrew, it meant not a single Yank would be around for the fourth round, writes Melissa Isaacson.
Just days after winning her first title, young American Madison Keys has developed a taste for titles. She kept her Wimbledon hopes alive with a first-round win over Monica Puig.
Sloane Stephens was more philosophical than heartbroken after her first-round Wimbledon loss to 109th-ranked Maria Kirilenko ended her streak of fourth-round appearances in majors at six.
If the past is any indication, the one thing to count on in the women's draw is that something weird will happen at Wimbledon this fortnight.
You'd be forgiven for giving up on Sam Querrey, but he's proving he's far from done.
Despite Serena Williams' disappointing fortnight, all was not lost for American women's tennis at Wimbledon. Sloane Stephens continued to shine and other young stars left lasting impressions.
In a field where Serena Williams still stands alone, young Americans Sloane Stephens, Madison Keys and Alison Riske are steadily rising up the ranks.
American teenager Madison Keys has a sizzling serve and rave reviews from Chrissie Evert and Serena Williams going for her heading into Wimbledon's third round.