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Skip Bayless and Stephen A. Smith are in NYC for MLB opening day and are debating several MLB hot topics with some special guests.

Rudy Giuliani says the Yankees and Derek Jeter will be fine. He doesn't think Mets owner Fred Wilpon would get involved with the Bernie Madoff Ponzi scheme. And he talks about the possibility of running for president.

Colin Cowherd is live at Mickey Mantle's for MLB's opening day. Cowherd believes more than half the teams have a fair shot to make the playoffs. His surprise team is Milwaukee.

The Big Show Live in NYC: Dan & Keith not tough enough on Bonds?, Barry crys.