Brazilian giants Cruzeiro hammered nine-man Real Potosi 7-0 to make it into the Copa Libertadores Group Stage.
Cruzeiro, runners-up last year, conceded a 1-1 draw with Real Potosi in the dying minutes of their Libertadores Cup preliminary round, first leg in the world's highest city in Bolivia.
Bolivar won the Bolivian Apertura championship when they beat Real Mamore 2-1 on the final day on Sunday, finishing a point ahead of Real Potosi to lift a record 16th league title.
Vanderlei Luxemburgo's Palmeiras qualified for the group stage of the South American Libertadores Cup by winning 2-0 to Real Potosi in a match played at 4,000 metres above sea level.
Vanderlei Luxemburgo's latest attempt to win the Libertadores Cup got off to an excellent start on Thursday when his Palmeiras side routed Real Potosi 5-1 in a preliminary round first leg tie.
Three players were sent off while a linesman and the visiting coach were hit by missiles as Bolivian championship leaders Oriente Petrolero were held at home by Real Potosi at the weekend.
A late penalty gave San Lorenzo a 3-2 comeback victory over Real Potosi on Tuesday, reviving the Argentine team's hopes of qualifying from Group 1 of the Copa Libertadores.
Real Potosi celebrated the first league title in their history for the second time in four days on Wednesday after being confirmed as Bolivian champions.
Real Potosi claimed to have won the Bolivian championship for the first time on Sunday but confusion surrounded their celebrations because they could still be deducted three points for fielding ineligible players.
Flamengo players were given bursts of oxygen on the touchline as they hit back to draw 2-2 away to Bolivia's Real Potosi at nearly 4,000 metres above sea level in the Libertadores Cup on Wednesday.
Five players were sent off as tempers flared in a Bolivian championship match at the weekend while a game in Paraguay produced 11 goals with 2 de Mayo beating Nacional 6-5.
Two players from Bolivian first division club Real Potosi were still in hospital on Monday after the team were involved in a bus crash on their journey home from a match at the weekend.
Bolivar won the Bolivian Apertura championship with four games to spare when they beat Real Potosi 1-0 away on Thursday.
A referee was attacked by a supporter who ran onto the field amid chaotic scenes at the end of the Bolivian championship game between Real Potosi and The Strongest at the weekend.