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National League MVP Ryan Braun, who last season led the Milwaukee Brewers to their first division title in nearly three decades, has tested positive for a performance-enhancing drug and faces a 50-game suspension.

Sources say that Manny Ramirez's own medical records clinched his 50-game suspension.

Unless the tight-lipped personal trainer for Barry Bonds suddenly decides to testify in the seven-time MVP's upcoming perjury trial, significant pieces of evidence in the prosecution's case will not be admitted, Judge Susan Illston ruled late Thursday.

Doping experts raise questions about Alex Rodriguez's claim that he didn't know what performance-enhancing drugs he was taking.

Former major league catcher Bobby Estalella is expected to provide significant testimony to support the government's contention that Barry Bonds knowingly took steroids, according a source with knowledge of the evidence.

Federal authorities and MLB are investigating Washington Nationals GM Jim Bowden and special assistant Jose Rijo for their possible roles in a growing financial scandal involving the signing of players from the Dominican Republic.

Within days of Greg Anderson's release from prison, his wife received a letter from federal prosecutors informing her that she is the target of a grand jury investigation, four people with knowledge of the BALCO steroids case told ESPN.

ESPN.com assesses the performance-enhancing drug policies of six major professional sports, and the NCAA, all measured against the so-called "gold standard" of testing for athletes in the Olympic movement.

Barry Bonds is scheduled to make another brief court appearance Friday in a hearing to determine if some of his attorneys have a conflict of interest in his federal perjury and obstruction case.

ESPN investigative reporters T.J. Quinn and Mark Fainaru-Wada say what jumps from the indictment is the revelation of "positive tests for the presence of steroids and other performance-enhancing substances by Bonds and other professional athletes."