Saturday, Pletcher is back at Tampa with Brethren, an undefeated half-brother to Super Saver who will be heavily favored against eight rivals to win the Grade 2, $350,000 Tampa Bay Derby, the centerpiece of a 12-race card at Tampa Bay Downs.
Nine weeks since she scored an impressive victory in the Grade 3 Senorita Stakes, Mrs Kipling will attempt to win the third stakes of her career in the $700,000 American Oaks at Hollywood Park on Sunday.
Red Rocks, the last horse to beat reigning Horse of the Year Curlin, will start in the Breeders' Cup Turf at Santa Anita on Saturday without a prep race in more than three months and a reputation for failing to put together consecutive wins.
With two graded stakes wins this year, Spring House has become the top turf marathon horse in California. He will need to do more to win his third major race in Saturday's $250,000 Clement Hirsch Turf Championship at Santa Anita.
Heatseeker has made a steady rise to the top of the California handicap division in the last six months. Staying there will require a win in the $750,000 Hollywood Gold Cup at Hollywood Park on Saturday.
Ismael Valenzuela, better known as Milo during a career that included 2,545 wins, will be inducted into the National Museum of Racing's Hall of Fame in a special ceremony at Santa Anita on Sunday evening.